Differential drug sensitivity patterns in myelodysplastic syndrome patients are recapitulated by ex vivo drug response profiling

Differential drug sensitivity patterns in myelodysplastic syndrome patients are recapitulated by ex vivo drug response profiling

Blood or bone marrow samples were red blood cell lysed upon arrival, counted and resuspended at the appropriate concentration in proprietary serum free media with cytokines. The samples were then plated in 384 well microtiter plates and treated with drugs in triplicate (for each staining panel) using an Echo acoustic dispenser.

Ex Vivo Drug Response Profiling Defines Novel Drug Sensitivity Patterns for Predicting Clincal Therapeutic Responses in Myeloid Neoplasms

Ex Vivo Drug Response Profiling Defines Novel Drug Sensitivity Patterns for Predicting Clincal Therapeutic Responses in Myeloid Neoplasms

Myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML) are clonal myeloid neoplasms for which limited conventional treatment options exist in the relapsed / refractory setting, especially for older patients.

Frequently Asked Questions (FAQ)

Frequently Asked Questions (FAQ)

Notable Labs is redefining cancer treatment by taking a functional approach to precision oncology in blood cancers. This cutting-edge science will facilitate drug development and enable pharmaceutical companies to get new therapies to patients faster.

Notable has developed a custom precision medicine platform that blends high-throughput flow cytometry with advanced automation and a streamlined analysis pipeline. This platform has been optimized to analyze drug sensitivity across many drug classes in primary patient...

Profiling of Rigosertib Identifies Distinct Classes of Responders in Myelodysplastic Syndrome

Profiling of Rigosertib Identifies Distinct Classes of Responders in Myelodysplastic Syndrome

Myelodysplastic syndromes (MDS) are clonal neoplasms with dysfunctional hematopoietic stem cells characterized by ineffective hematopoiesis, cytopenias, and have a substantial risk of transformation to AML.

Myelodysplastic syndromes (MDS) are clonal neoplasms with dysfunctional hematopoietic stem cells characterized by ineffective hematopoiesis, cytopenias, and have a substantial risk of transformation to AML. The hypomethylating agents (HMAs) azacytidine and decitabine are the standard...

Notable’s The ANSWer Study

Notable’s The ANSWer Study

Notable’s The ANSWer Study: An Observational Clinical Trial for Patients with Blood Cancer by Susanna Wen MsM (Master of Medicine), Ph.D Notable’s first self-sponsored clinical trial to validate cancer patient matching on its automated high-throughput scientific technology platform At Notable, we are aiming to redefine cancer treatment with the development of a functional precision medicine […]

What is precision medicine?

What is precision medicine?

In the world of oncology, precision medicine has been synonymous with genomics. Once genetic abnormalities are identified in a patient through cytogenetics and sequencing, an appropriate therapy can be identified that exploits this abnormality thought to be driving cancer growth. One of the best success stories… oncology precision medicine has been the genetic.