We developed an epigenetic approach to profile the gene regulatory landscape of primary AML/MDS patient samples. A novel patient subset defined by RARA pathway activation was identified by super-enhancers (SEs) at the RARA and IRF8 gene loci.
Bone marrow biopsies (H&E) at 40x from screening (A) and C3D1 (B). Bone marrow aspirate (WG stain) at 100x from screening (C) and C3D1 (D). (A) Blasts (black arrows) occur in many small groups. Maturing myeloid cells (yellow arrows), erythroid precursors (red arrows) and megakaryocytes (blue arrows) are also present.
Notable Labs uses a flow cytometric-based assay to test a panel of FDA-approved chemotherapy and targeted agents—singly and in combinations using a custom robotic platform—to determine anti-cancer effect against individual patient’s tumor cells.
Blood or bone marrow samples were red blood cell lysed upon arrival, counted and resuspended at the appropriate concentration in proprietary serum free media with cytokines. The samples were then plated in 384 well microtiter plates and treated with drugs in triplicate (for each staining panel) using an Echo acoustic dispenser.
Myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML) are clonal myeloid neoplasms for which limited conventional treatment options exist in the relapsed / refractory setting, especially for older patients.
Notable Labs is redefining cancer treatment by taking a functional approach to precision oncology in blood cancers. This cutting-edge science will facilitate drug development and enable pharmaceutical companies to get new therapies to patients faster.
Notable has developed a custom precision medicine platform that blends high-throughput flow cytometry with advanced automation and a streamlined analysis pipeline. This platform has been optimized to analyze drug sensitivity across many drug classes in primary patient...
Myelodysplastic syndromes (MDS) are clonal neoplasms with dysfunctional hematopoietic stem cells characterized by ineffective hematopoiesis, cytopenias, and have a substantial risk of transformation to AML.
Myelodysplastic syndromes (MDS) are clonal neoplasms with dysfunctional hematopoietic stem cells characterized by ineffective hematopoiesis, cytopenias, and have a substantial risk of transformation to AML. The hypomethylating agents (HMAs) azacytidine and decitabine are the standard...
FOSTER CITY, CA – June 23, 2020 (GLOBE NEWSWIRE) — Notable, which is redefining cancer treatment by taking a functional approach to precision oncology in hematological cancers, announced today that the results of a Stanford study using its drug sensitivity screening platform have been published in Blood Advances (June 23, 2020; Volume 4, Issue 12).
Notable’s The ANSWer Study: An Observational Clinical Trial for Patients with Blood Cancer by Susanna Wen MsM (Master of Medicine), Ph.D Notable’s first self-sponsored clinical trial to validate cancer patient matching on its automated high-throughput scientific technology platform At Notable, we are aiming to redefine cancer treatment with the development of a functional precision medicine […]
FOSTER CITY, CA – April 30, 2020 — Notable, which is redefining cancer treatment with its scientific technology platform to rapidly advance drug development, announced a partnership today with the MDS Foundation. MDS Foundation (MDSF) provides insight and information to families on upcoming clinical trials for myelodysplastic syndrome (MDS). As part of the partnership, Notable […]